Discrimination of influenza A subtype by antibodies recognizing host-specific amino acids in the viral nucleoprotein
نویسندگان
چکیده
منابع مشابه
Replication-coupled and host factor-mediated encapsidation of the influenza virus genome by viral nucleoprotein.
The influenza virus RNA-dependent RNA polymerase is capable of initiating replication but mainly catalyzes abortive RNA synthesis in the absence of viral and host regulatory factors. Previously, we reported that IREF-1/minichromosome maintenance (MCM) complex stimulates a de novo initiated replication reaction by stabilizing an initiated replication complex through scaffolding between the viral...
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The nucleoprotein (NP), which has multiple functions during the virus life cycle, possesses regions that are highly conserved among influenza A, B, and C viruses. To better understand the roles of highly conserved NP amino acids in viral replication, we conducted a comprehensive mutational analysis. Using reverse genetics, we attempted to generate 74 viruses possessing mutations at conserved am...
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ژورنال
عنوان ژورنال: Influenza and Other Respiratory Viruses
سال: 2012
ISSN: 1750-2640
DOI: 10.1111/j.1750-2659.2012.00335.x